PureScript vs Flow
When comparing PureScript vs Flow, the Slant community recommends PureScript for most people. In the question“What are the best solutions to "The JavaScript Problem"?” PureScript is ranked 5th while Flow is ranked 32nd. The most important reason people chose PureScript is:
Has Typeclasses and RankNTypes
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Higher kinded types
Has Typeclasses and RankNTypes

Pro High performance FFI code
The Eff monad, which is used for FFI code, optimizes out calls to bind, and supports tail call optimization, resulting in clean, efficient Javascript. The psc compiler also specifically recognizes the ST monad, and transforms scoped variables into mutable Javascript variables, for even more efficient code.
Pro Type safety
Compiling should be your first unit test. A tight type system (static and hopefully strong) will catch many logic errors that are often difficult to spot through debugging. In languages like PureScript, if it compiles, it often runs properly.
Pro Pure functional language
You cannot have side effects, unless a function is explicitly defined as so.
Pro Modules can be compiled to CommonJS
Modules compiled to CommonJS can be included with 'require', making it incredibly simple to call Purescript code from Javascript.
Pro Has row polymorphism and extensible effects
Pro FFI
FFI system is quite good and easy to use. You can import functions curried or not curried. Records and arrays use native JS objects and arrays.
Pro Thorough documentation
The Purescript website has fairly thorough documentation for all of the language's features, and the Purescript blog contains several examples of practical usage.
Pro Awesome web frameworks
Thermite (React)
Halogen (VDOM, similar to ELM)
And hit these up with Signals, Isolated/(Managed?) Components, powerful functions and FFI

Pro Checks to see if you check for Nulls
Because getting those exceptions is just not fun and very pervasive.
Pro Versioned type definitions
Pro There is support in many code editors via the extension
For example, there is good support through the extension in Visual Studio Code, which is a good editor for TypeScript, which is a competitor to Flow.
Pro Babel extension for strip of type annotations
Thanks to the Babel extension for the output, there is minimally modified code that is understandable to the author.
Pro Statical analysing of JavaScript code
Statical analysing of JavaScript code without pre-making any changes to it. But supported annotation types by extending the syntax of the language.
Cons
Con Lots of dependencies needed to get started
Purescript is written in Haskell, but meant to be used with Node.js. As a result, to get started , users must install ghc, cabal, node.js, grunt, and bower. Purescript also has its own compiler, and different semantics form Haskell, and so even after installing, there's still some overhead to getting productive with Purescript.
Con Lack of good IDE/tooling support
Con Documentation not updated
Con Ecosystem not stable
Con Restrictive FFI
Functions exported are all curried, and must be called as such from Javascript. The FFI syntax for importing Javascript functions, while slightly simpler and more readable than UHC/Fay's, means that calls to methods on objects must be wrapped to pass the object explicitly as a parameter.
Con Slow compilation
On large project, for example Halogen
Con Weak base type definitions even for popular JavaScript libraries
For example, there are definitions for Gulp, React.
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