When comparing Prezi vs Keynote, the Slant community recommends Keynote for most people. In the question“What are the best presentation programs?” Keynote is ranked 5th while Prezi is ranked 6th. The most important reason people chose Keynote is:
Can import all kinds of assets (images, videos, PDFs, sounds) into mockup without hassle.
Specs
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Pros
Pro Easy to collaborate with co-workers/friends
Another benefit of it being a web-app is how simple it is to collaborate on presentations.
Pro Accessible online with storage
Accessible online so all your work stays online (in case your computer breaks) while it has a cool and easy to use templates and designs.
Pro Lets you create beautiful presentations that flow well
Prezi helps you create presentations that tell a story. The UI lets you create a storyboard for the presentation so it's really easy to design the big picture for the presentation and then drill down to the individual "slides".
Pro The Storyboard UI makes it easier to think through presentations
Instead of being constrained by individual slides, Prezi lets you input all the various text & media you want to cover and then organise it into a logical flow later on.
Pro Cross-platform with sync
There is a fully featured web-app as well as apps for Windows, Mac & iOS (iPhone & iPad). All the files sync across the platforms platforms so you don't need to worry about managing files etc.
Pro Imports nearly every type of asset
Can import all kinds of assets (images, videos, PDFs, sounds) into mockup without hassle.
Pro Animations and transitions
Keynote currently is one of the very few tools that supports animation of elements and transition of views without programming.
Pro Text Styles makes it easy to create typography systems
Pro Smart Snaps
Keynote has alignment grids (aka snap to grid feature) that snaps to end, midpoints, baselines etc of objects and grids. They are super useful when you want to follow a structured layout for your wireframe.
Cons
Con Might run slow
On lower end systems it might be a little too slow, so you have to take into account what systems are you planning to present on.
Con Online only
This presentation application is only available through a browser, with the data hosted on Prezi servers, with all the obvious privacy concerns it induces.
Con Freemium
Limited to create a different presentation and privacy control, revocable share link, etc only for premium user.
Con The transitions are a distraction from your content.
Prezi encourages you to use gimmicky, distracting transitions.