When comparing Tweedle vs Twidere, the Slant community recommends Twidere for most people. In the question“What are the best Twitter clients for Android?” Twidere is ranked 1st while Tweedle is ranked 6th. The most important reason people chose Twidere is:
The source code is available under the GPLv3.
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Pros
Pro Great theme customization
You can choose between 5 different themes, including light and dark themes. You can also manually set up Tweedle colors yourself, choose to display avatars or not and what you want actionbar to look like.
Pro Detailed notification settings
You can have separate notification settings for your timeline, mentions and direct messages for each account. Refresh time can be set between a minute and 4 hours.
Pro Customizable columns
You can customize what columns you want shown - home, mentions, messages, favorites, retweets, trends, search and lists.
Pro Embeds photo & video previews
Tweedle embeds previews of photos and videos in your timeline.
Pro Multiple user support
Allows for easy switching between different Twitter accounts within the app.
Pro SSL encryption
You can have all your communication with Twitter encrypted.
Pro Real-time notifications
You can choose to have instant push notifications when on Wi-Fi.
Pro Mute function
You can remove tweets of a user from your timeline without having to unfollow them. As well as mute specific words or hashtags.
Pro In-app browser
Allows following links without having to leave the application.
Pro Free software/open source
The source code is available under the GPLv3.
Pro Modern UI
Pro Very customizable
The user can add and arrange his/her own tabs with specific views and filters.
Pro Supports custom API
It supports API customization, so you don't need to worry about API limits at all.
Pro Works as expected
Pro Handles Mastodon, Fanfou and StatusNet too
You need only one app to read Twitter and Mastodon.
Cons
Con Avoid, not userfriendly
Merges multiple accounts into one timeline and there is no way to get around that. This is ridiculous. only recommended if you have one account. Seeing one timeline is impossible. The app appears to be a copycat of Plume minus the ads in many ways. The app is missing the translate feature. The Trends feature doesn't work. Interactions missing features too. It's not intuitive as well, rather complicated. So very few downloads.