When comparing TYPO3 vs ExpressionEngine, the Slant community recommends TYPO3 for most people. In the question“What are the best web content management systems?” TYPO3 is ranked 11th while ExpressionEngine is ranked 14th. The most important reason people chose TYPO3 is:
You can use both one-tree and multi-tree structure.
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Pros
Pro Flexible multi-lingual site management
You can use both one-tree and multi-tree structure.
Pro Multiple websites/domains from one installation
You can use a single TYPO3 installation for multiple websites and domains.
Pro TYPO3 is enterprise
TYPO3 can be used from small to very big installations where it is possible to give rights to users on a very fine grained basis.
Pro No restrictions on how a site can be designed
Pro Focus on security
Pro Commercial support
Cons
Con Writing or debugging extension in Typoscript is a nightmare
Con Simple pages can hurt performance
A simple page can rack up on database queries. Many sites usually suffer from this. Create an empty page and there's a few queries that run and it's unneccessary.
Con Can be overkill for simple or smaller sites
Con Cost is high
Especially for commercial sites
Con Built on top of codeigniter: an outdated framework
Codeigniter was cool.... back when PHP was at 5.2