When comparing Notepad++ vs PyScripter, the Slant community recommends PyScripter for most people. In the question“What are the best Python IDEs or editors?” PyScripter is ranked 15th while Notepad++ is ranked 29th. The most important reason people chose PyScripter is:
PyScripter is a lightweight Python IDE.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Syntax highlighting for a wide variety of languages
Notepad++ has built-in support for syntax highlighting for a wide selection of programming languages.
Pro Light and fast
Notepad++ is a very light program that starts almost instantly. This makes it a great text editor for users that want something that will start the second they open it.
Pro Extendable via plugins
A list of hundreds of plugins is maintained.
Pro Portable
You can get a portable version of N++ and put it on a flash drive or your dropbox account and have your editor, configured the way you like, at any computer that you are on.
Pro Free under GPL
Notepad++ is licensed under GPL, which means it is free/open source software that you can use freely.
Pro Regex replace in selection, active tab, or all tabs
In Notepad++, the user can utilise regular expressions to quickly modify text across multiple files.
Pro Persistent documents, even after exiting the application
If you close Notepad++ (npp), your documents remain even if you haven't saved.
Pro User defined language syntax support
You can define your own custom syntax highlighting rules (or add support for others) .
Pro Easy to use and admin
Very easy to use and personalize.

Pro Multi-line editing
While it is disabled by default, when enabled, it is possible to edit more than one line at a time. This is helpful in many situations.
Pro Split screen
The user can open and edit files in multiple screens within the editor window.
Pro Supports Markdown
If you have the Plugin Manager installed you can search for MarkdownViewer++ and install it via that plugin.
Pro Lightweight
PyScripter is a lightweight Python IDE.
Pro Easy to use
Covers the needs of advanced users (thread debugging, unit testing etc.).
Pro Superb for interactively developing scripts
When you run a program, the context is automatically available in the Python interpreter afterwards, without having to set breakpoints.
Pro Easy to set up
No configurations needed. Just download and code.
Cons
Con Windows-only
While it can run in Wine, it is native only to Windows. Linux users will have to use Notepadqq instead.
Con Settings confusingly scattered
Examples: try to change the tab size or used font.
Con Annoying update notifications upon start-up
Annoying update notifications tend to pop up upon start-up after not having used the app or machine for a few days. At the same time, they can be easily turned off.
Con Outdated UI
Only the text area can be themed, and it doesn't have as many features as browser-based text areas.
Con Limited new syntax support for new languages
It may be hard to find good plugins for relatively new languages.
Con Session backups not enabled by default
Unsaved tabs will be lost when Npp crashes, unless you first enable the session backup option.
Con User defined language doesn't support triple quote strings
It also doesn't support triple hashed comments. Both styles are overridden by their single character single line version.
Con Windows only
Available for Windows only.
Con Noticeably unstable since v.4
Frequently hangs/freezes, esp. when debugging.
Con Refactoring is not that easy
In Pyscripter, refactoring pretty much leans on traditional dumb find-and-replace.
