When comparing Omnifocus vs Priority Matrix, the Slant community recommends Priority Matrix for most people. In the question“What are the best cross-platform task apps?” Priority Matrix is ranked 47th while Omnifocus is ranked 63rd. The most important reason people chose Priority Matrix is:
Priority Matrix helps me focus on what's truly important on my todo list, so I can work more efficiently.
Specs
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Pros
Pro Defer date
Omnifocus allows users to setup the "defer date" which can be treated as "start date". Tasks will not be marked as available until that date, which should help to focus on the "available" task only.
Pro Forecast summary
The forecast summary shows a quick digest of the tasks you have for the day. You can select any day to quickly see what tasks you have planned that day. For extra functionality you can connect with the iPhone’s Calender app, which allows you to also see any other events you have planned that day.
Pro See an overview of all tasks via "Perspective"
The Perspective section allows you to see an overview of the tasks you have set. It also allows you to set contexts or see things you have flagged.
Pro Nearby and context-sensitive tasks
OmniFocus 2 allows you to set up contexts for tasks in certain areas. This makes sure you never miss a task when you're out running errands and happen to be near something you need to do.
Pro Helps prioritize, rather than simply listing tasks
Priority Matrix helps me focus on what's truly important on my todo list, so I can work more efficiently.
Pro Super easy to share / delegate tasks
All I have to do is press a button, rather than drafting a whole email to one of my co-workers.
Pro Solid methodology
The software implements time proven methodologies; not just a to-do list.
Pro Lots of different views
Priority Matrix makes it really easy to see your task list in different ways: You can see it in the quadrant view, calendar view, a filterable list, and also a Gantt Chart if you have the business license.
Full disclosure: Originally posted by an Appfluence Intern (who was equally impressed with the software's layout and functionality before working there)
Cons
Con Mac and iOS only
Omnifocus doesn’t work on non-Apple platforms.
Con Expensive
Used to be free, is now $12+ a month.