When comparing Abstra vs PySide, the Slant community recommends PySide for most people. In the question“What are the best Python GUI frameworks/toolkits?” PySide is ranked 7th while Abstra is ranked 11th. The most important reason people chose PySide is:
Qt for Python aka PySide2 is the official set of Python bindings supported by the Qt Company.
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Pros
Pro Modern looking UIs
Widgets have a sleek and modern design.
Pro Drag-and-drop UI editor
Makes it very easy and fast to create the app's look, then just plug it into the script using variables and functions.
Pro Supported by the Qt Company
Qt for Python aka PySide2 is the official set of Python bindings supported by the Qt Company.
Pro Qt widgets
Possibility to use a traditional widget-based user interface.
Pro QtQuick/QML
Possibility to use a declarative approach to define the user interface.
Pro Weak copyleft
PySide is licensed under the LGPL, which makes it easier to incorporate into commercial projects than PyQt.
Cons
Con Similar to PyQt, you need a C++ background. at least you can read C++ code
Qt's document is poor, and Qt for Python(PySdie) is even worse. this document assumes that you are already familiar with Qt. if you want to customize a Widget, you need to look at the Qt C++ source code to know what to do.