When comparing Virtual Box vs Little Snitch, the Slant community recommends Little Snitch for most people. In the question“What are the best Mac OSX apps for someone that's new to Apple?” Little Snitch is ranked 7th while Virtual Box is ranked 15th. The most important reason people chose Little Snitch is:
Little Snitch rules work even at login screen. Even when receiving attempted connection alerts, once logged in LS has stopped and requested permission for them.
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Pros
Pro Compatible with Many Operating Systems
It works for Windows, macOS, Linux, BSD, and many others.
Pro Beginner friendly
A virtual machine can be set up in minutes if a ISO file to load is already available.
Pro Works well and fast for Windows host and Linux guest
Pro Free and open source
Pro Many free images available
Though most are linux flavors at https://virtualboxes.org/
Oracle's virtualbox site has others.
Pro Can do snapshots
Pro A lot of customization
VirtualBox has multiple virtualization options. Each one may be tailored to the guest operating system’s needs. This makes it especially good on virtualizing older systems, such as DOS, obscure distros, etc.
Pro Protected even at login screen
Little Snitch rules work even at login screen. Even when receiving attempted connection alerts, once logged in LS has stopped and requested permission for them.
Pro Comparatively easy to use
Easier to use than traditional firewall software, but more powerful due to design and workflow.
Pro Protects your privacy
Protects your privacy and helps to prevent unwanted connections.
Cons
Con Lacks video performance
Virtualbox has a hard cap of 256MB of video memory. This could make newer operating systems run slower.
Con Minimal CPU customization
You can only enable/disable certain features. You cannot cap the speed of the CPU, which is required to run systems such as Windows 95.