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When comparing Virtual Box vs IINA, the Slant community recommends Virtual Box for most people. In the question“What are the best Mac OSX apps for someone that's new to Apple?” Virtual Box is ranked 15th while IINA is ranked 16th. The most important reason people chose Virtual Box is:
It works for Windows, macOS, Linux, BSD, and many others.
Question Ranking
Pros
Pro Compatible with Many Operating Systems
It works for Windows, macOS, Linux, BSD, and many others.
Pro Beginner friendly
A virtual machine can be set up in minutes if a ISO file to load is already available.
Pro Works well and fast for Windows host and Linux guest
Pro Free and open source
Pro Many free images available
Though most are linux flavors at https://virtualboxes.org/
Oracle's virtualbox site has others.
Pro Can do snapshots
Pro A lot of customization
VirtualBox has multiple virtualization options. Each one may be tailored to the guest operating system’s needs. This makes it especially good on virtualizing older systems, such as DOS, obscure distros, etc.
Pro Like MPV with better GUI and settings
It's like mpv, just more user friendly GUI and more settings available via UI.
Pro Extremely stable
Extremely stable, even while still in the beta.
Pro Support for lots of codecs
Supports lots of video codecs, like mp4, mkv, etc, and lots of audio codecs including opus.
Pro Doesn't black out other displays when going full screen
It can black out other screens if you want, but out of the box it leaves your other displays alone.
Pro Runs on MPV so it's scriptable and runs any MPV script.
More information here.
Tip: if you're doing a lot of cropping and slicing of videos and you thought the new quick tools in Finder / Quicktime Player are a great improvement, try setting up IINA with slicing.lua and some keybindings for navigating your video + setting the slicing positions.
Make sure your ffmpeg command (in slicing.lua) is set to copy the original codecs and that it's using your GPU.
Pro Online subtitle searching and intelligent local subtitle matching
Pro Fully customizable keyboard, mouse, trackpad, and gesture controls
Pro Open source
Pro Powered by FFmpeg
Cons
Con Lacks video performance
Virtualbox has a hard cap of 256MB of video memory. This could make newer operating systems run slower.
Con Minimal CPU customization
You can only enable/disable certain features. You cannot cap the speed of the CPU, which is required to run systems such as Windows 95.
Con Unstable
May crash unexpectedly, while clicking on something in the subtitles section in the right-hand panel, for example.
Con Blacks out other displays when going full screen
