When comparing Inkscape vs Affinity Designer, the Slant community recommends Inkscape for most people. In the question“What are the best vector graphics editors?” Inkscape is ranked 1st while Affinity Designer is ranked 3rd. The most important reason people chose Inkscape is:
Inkscape is GPL-licensed and maintains public repositories.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Free and open source
Inkscape is GPL-licensed and maintains public repositories.

Pro Opens lots of file types
Inkscape supports many common formats for import (including SVG, Photoshop and Illustrator) and its plugin architecture allows more to be added.
Pro Export to different file types
Files can be exported and saved as a "normal" svg, png, jpg, bmp etc. file.

Pro Cross-platform
Pre-built binaries are available for Windows, Mac and Linux. Inkscape can be built from source on additional platforms.
Pro Integrates well into a X11-System
Its uses the X11 icon theme and desktop theme(GTK).
Pro It can do anything
A very powerful software that can do pretty match anything!
Pro Measurement Tool
This tool is extremely handy and can not be found in any other vector graphics programs out there.
Pro Live Path Effects
Extremely powerful menu that offers more than 30 powerful Live Path Effects to apply to paths vastly enhancing the application functionality.
Pro Guides, Grids, and Canvas Rotation
Extremely handy features when building complex graphics using Inkscape.
Pro Dark Theme Support
The new 1.0 beta 2 version finally got support for dark theme which normally is only available for commercial software like Affinity Serif, Adobe Illustrator.
Pro The new version 1.1 is looks and feels fantastic
Inskape got UI update: new dockable dialogs.
Pro Interface is available in 29 languages
Basque, British English, Brazilian, Portuguese, Catalan, Croatian, Czech, Dutch, Finnish, French, German, Greek, Hindi, Hungarian, Icelandic, Indonesian, Italian, Korean, Latvian, Norwegian (Bokmål), Polish, Romanian, Russian, Slovak, Spanish, Swedish, Turkish, Ukrainian, Urdu, Swedish.
Pro It's really easy and fun
Vector graphics can be created and edited with Inkscape.
Pro One-time purchase
Rather than a monthly subscription based model, Affinity Designer instead has a one-time fee ($49.99).
Pro Intuitive user interface
The user interface of many graphic editing software programs can often be discouraging for beginners. Affinity Designer, however, has a very well laid out and intuitive user interface with a small learning curve.
Pro Powerful artistic tools
Extensively tweakable brush types, color options...
Pro Extended slicing and export possibilities
An object can easily be transformed into a slice that can then be exported in various sizes end formats in 1 go. E.g. Export slice A as PNG 1x, 2x and 3x AND GIF 1x AND SVG.
Pro Powerful symbol managemment
Symbols can get individual property changes (color, shape, layer effects, fonts text...) while the other properties stay linked with the base symbol.
Pro Sketch Alternative (Great for Mixed OS Teams)
For those working in mixed environments that aren't 100% MacOS, you'll find devoting yourself to Sketch.app brings with it...pain. If this fits the bill for what you need feature-wise and you're in a mixed OS environment, it's a very capable replacement for Sketch.app. Note that it doesn't have all the same features, but then again it doesn't need all the same features. Short of organization differences inside the document you're working on, there shouldn't be anything you can't do with Affinity Designer that you could have with Sketch.
Pro Cross platform
Available on both Windows and MacOS
Pro SVG Support
In the era of "retina" displays, 4k UHD, 5k, and even 8k, Scalar Vector Graphics - independent vector images that can scale to any resolution without any display quality loss - are more important now than ever.
And this tool is quite capable of rendering true SVG output suitable for consumption at any display resolution (not a big bunch of rasterized bits in the document, actual paths, points, etc.).
Pro Focused vector graphics tool
Unlike some design tools, Affinity Designer isn't trying to be all things to all people. It's focused on its main area of expertise: vector graphics. That's not to say you can't use a raster image (think a photo in *.jpeg format for example), but it's not built to do much with that other than using it somewhere amidst the layers and that's about it.
Pro Integrates well with Affinity Photo
These are companion apps & switching between them is built in - Photo is a very powerful raster tool with a feature set close/better to Photoshop, it will also use some Photoshop plugins. This allows you to add-on powerful raster capabilities if you want them - put doesn't force you to.
Pro Excellent Photoshop/Illustrator import & export
Best I have seen in a non Adobe app, you can use most of the Photoshop mock-ups and templates easily. Opens most Adobe files to a level to be able to effectively use the content. Allows cross team collaboration across tool-chains.
Pro Powerful
The new version 1.5 has a very powerful feature set such as support for symbols and asset windows, as well as constraints controls and improved export options. This all adds up to an interesting alternative to Adobe Illustrator.
Cons

Con Very slow startup on some systems
Depending on factors like how many fonts you have installed, Inkscape can take upwards of 30 seconds to launch.
Con Uses its own SVG-format by default
Inkscape might use SVG as its default format, however this SVG's contains some additional SodiPodi/Inkscape additions that can be troublesome if you want to import the SVG into some other application.
Con 1.0 is sluggish
Inkscape 1.0 uses GTK 3 which is sluggish and slow for low spec systems( eg. ARM, Celeron, Pentium, Core-i3, Ryzen 3 or Athlon ) compared to previous versions.
Con Buggy
Application is often buggy so it happens from time to time that the popup / right-click menu won't close and stays open. It crashes also sometimes randomly. This makes it almost unusable for productive / business use.
Con Crashes very often
Inkscape encountered an internal error and will close now - is one of its standard messages.
Con Since 0.91 the gradient editor is gone
It is now only possible to edit a gradient on screen. but you can't set a stop to a specific percentage anymore.
Con Limited work with ICC CMYK color scheme
Support for ICC color profiles only in SVG files.
Con Uses GTK
It looks an feels like an alien. It also uses now touch-based widgets instead of professional widgets.
Con Y-axis inverted
0,0 coordinates begin in lower left corner, not upper left corner as SVG standards define in Inkscape 0.92.x.
It seems this is now fixed in the 1.0 beta 2 version of the program.
Con A toy for facebook-ist enthusiasts, not for professionals
It's a Linux niche mumbo-jumbo, same as GIMP for raster edit .
Con Based on the GTK widget toolkit
Software is based on GTK, so it might not integrate well in non-GTK environments. It also requires many dependencies on those non-GTK desktops. It also adds dependencies to GTK-environments since it is written in C++ which requires the gtkmm wrapper/interface.
Con Mac version does not look as polished as its versions for Windows/Linux version for the 0.92.x version
It seems that Inkscape 1.0 beta 2 for Mac got some needed attention and it looks a lot better with dark theme support. native DMG installer and they got rid of X11 which is great.
Con Incompatible with previous versions
Sometimes backward compatibility breaks. For example, pre 0.92 SVGs are incompatible with later releases (due different default resolutions).
Con No support for large printing machine system
No support for large printing machine environment, except exporting the resulting artwork to PDF.
Con Under GNU GPL
It is released under GNU GPL which one of the restricted open source license.
Con No plug-in architecture, so can't be tailored to specific purposes
Some applications (e.g. Sketch) have an open plug-in framework, by which the software can be extended by independent/third-party developers according to popular trends.
Con Treats all objects as filled
You can't select objects on the canvas by clicking on them, if they're surrounded by another object (like a rectangle or a frame). Designer treats all objects as filled, so if you've drawn a frame or outline or an object with a hole in it, you can't select objects within that hole directly. You have to laboriously iterate through all objects in a list until you get to the one you want. This is an extremely common situation, which cripples the entire product. Very surprising and unfortunate defect.
