When comparing Skeleton vs Pure CSS from Yahoo!, the Slant community recommends Skeleton for most people. In the question“What is the best CSS framework?” Skeleton is ranked 6th while Pure CSS from Yahoo! is ranked 12th.
Ranked in these QuestionsQuestion Ranking
Pro Responsive grid
Pro Style agnostic
Pro Vanilla CSS
No bells and whistles for Skeleton, it's just CSS.
Pro Media queries
Pro Easy to customize
Has an extremely minimalist look that is super-easy to customize since it basically gives designers just a foundation on which they can easily build their design.
Pro Cross-Browser compatibility
A solid base built on Normalize.css to fix cross-browser compatibility issues.
Extremely small file size: 4.5KB minified + gzip.
A responsive grid that can be customized to your needs.
Pro Works well with Bootstrap
Easily use Bootstrap CSS and JS elements within the framework.
Con Not maintained anymore
No active development for two years.
Con Not suitable for beginners
Since Pure CSS only carries a minimum number of styles out of the box, it might not be great for beginners who want a complete style that looks good out of the box without having to customize it.