When comparing Skeleton vs Topcoat, the Slant community recommends Skeleton for most people. In the question“What are the best minimal CSS frameworks?” Skeleton is ranked 13th while Topcoat is ranked 18th.
Ranked in these QuestionsQuestion Ranking
Pro Responsive grid
Pro Style agnostic
Pro Vanilla CSS
No bells and whistles for Skeleton, it's just CSS.
Pro Media queries
Pro Focused on performance
Every Topcoat component is built with performance in mind. Most of the stylesheets are small and do not take too long to load.
Con Not maintained anymore
No active development for two years.
Con Not so impressive design
But it is themeable.
Con Some issues with typography
For some components the text size is quite small, while for others it's too light over a light background, making the text harder to read.