When comparing UDK vs uScript + Unity3D, the Slant community recommends UDK for most people. In the question“What are the best 2D game engines?” UDK is ranked 73rd while uScript + Unity3D is ranked 97th. The most important reason people chose UDK is:
UDK has an extremely large toolset that allows creating almost anything without having to use a 3rd party tool or plugin.
Specs
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Pros
Pro Large toolset
UDK has an extremely large toolset that allows creating almost anything without having to use a 3rd party tool or plugin.
Pro Triple A track record
UDK is an engine used by many big name companies for popular games such as the Gears of War series.
Pro Automatically generates nodes for third-party script assets
uScript's nodes are a visual representation of actual code blocks, and it takes advantage of C#'s reflection capabilities to automatically create nodes for any scripts it finds in your project, regardless of the source. This makes it inherently compatible with pretty much everything.
Custom nodes can also be created by hand, for cases where the automatically created ones contain more elements than they actually need.
Pro Versatile flow diagram script model
Modeled after UDK's Kismet (the predecessor to UE4's Blueprint), uScript's scripts resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.
Pro Generates C# source code
Nodes are translated directly to C# files in your project. This is great for learning to code, and also for advanced users who can use uScript for fast prototyping and then further optimize the scripts if necessary.
Cons
Con Superseded by Unreal Engine 4
Con DevKit only runs on Windows
Even though UDK can deploy games to run on multiple platforms, including Mac, it does not feature support for development on Mac.
Con Limits games to FPS
UDK was originally developed for the FPS, "Unreal Tournament", and it certainly shows. While UDK is a very powerful engine, it takes quite a bit of work to make it do something other than an FPS.
Con Not that easy to use
It's a lot more complicated compared to something like Playmaker. Same tasks take a lot more time.