When comparing Stride vs Unity 2D, the Slant community recommends Unity 2D for most people. In the question“What are the best 2D C# game engines?” Unity 2D is ranked 2nd while Stride is ranked 6th. The most important reason people chose Unity 2D is:
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Good looking and fast
Looking nearly as good as Unreal Engine 4, but rendering significantly faster.
Pro No royalties or licensing fees
Pro Projects are normal Visual Studio solutions
No proprietary project format, so it works with all the official .NET tooling.
Pro Supports Visual Studio
Pro Very modern render engine
Pro Powerful 3D Rendering Engine
Supports Vulkan. You can achieve good quality as in Unity3d and Unreal Engine

Pro Straightforward editor
Stride provides a simple and clean working environment for designing games.
Pro Community seems friendly and is growing
Pro Engine AND Scripting are both C#
Since the engine is written in the same language as the scripting, there is no weird mix of technologies as other engines have.
Pro Supports Vulkan
Currently the only well known open-source game engine that supports Vulkan, and probably one of the only.
Pro Easy to learn and use C#
Pro Multiple Starter Templates
The engine comes packed with multiole example projects to help you get started.
Pro Built into Unity 4.3+
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Pro Integrates with Mecanim
Mecanim brings state machines and blending to 2D bone animation. The state machine editor allows for designers and programmers to visually create a Finite State Machine (FSM) to control when animations should play. Mecanim also allows for blending so an animation can transition smoothly between two states without the need of in between frames made by an animator.
Pro Sprite Sheet and Bone based animation supported
Both types of 2D animation for game development are supported in Unity’s system and can be used interchangeably in the timeline.
Pro Easily change sprites dynamically
Usually used for character customization, programmers can change any sprite in a bone animation at runtime easily by referencing the bone and loading the new sprite from the resources folder.
Cons
Con No terrain editor
Unless you like working on planes, there is no terrain support.
Con Editor is Windows only
Since version 1.7, Linux can be targeted for runtime. The editor for the engine is available only to Windows though.
Con Small user community
Unity and UE have a vast amount of user community.
Con Does not currently support Playstation or Switch games
Con Iteration may be slower than with other engines due to longer "build" times when certain changes are made
Con Shader system require's overhaul
Shader's are not easy to get to grips with and Stride's shader system. Needs overhauling for easier use.
Con Lacks critical features
- Vertices can't be animated, so you can't have ANY organic feel (like... lungs breathing).
- Parent bone can't be animated without affecting the children. This is especially impeding for organic feel, again.
- No option to show & unshow assets (or it is hidden), like for switching weapon on your character for exemple.

Con Poor script interface for texture atlases
Accessing individual sprites within an atlas texture is possible at runtime, but requires use of the Resources folder subsystem.
