When comparing Inuitcss vs Topcoat, the Slant community recommends Topcoat for most people. In the question“What are the best minimal CSS frameworks?” Topcoat is ranked 19th while Inuitcss is ranked 21st. The most important reason people chose Topcoat is:
Every Topcoat component is built with performance in mind. Most of the stylesheets are small and do not take too long to load.
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Pros
Pro Extensibility
Inuit.css is highly modular. It uses plugins, called igloos, to extend its functionality with features such as breadcrumbs, IE6 support, dropdown menus, etc.
Pro Highly modular
Pro No style lock-in
Pro Focused on performance
Every Topcoat component is built with performance in mind. Most of the stylesheets are small and do not take too long to load.
Cons
Con Not released yet
As of July 2015, the website says "Coming soon".
Con Not so impressive design
But it is themeable.
Con Some issues with typography
For some components the text size is quite small, while for others it's too light over a light background, making the text harder to read.