When comparing PikoPixel vs PyxleOS, the Slant community recommends PikoPixel for most people. In the question“What are the best pixel art / sprite editors?” PikoPixel is ranked 19th while PyxleOS is ranked 26th. The most important reason people chose PikoPixel is:
You can change the canvas background to a different texture and color, while you can also adjust the texture size.
Specs
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Pros
Pro Customizable canvas background
You can change the canvas background to a different texture and color, while you can also adjust the texture size.
Pro Customizable UI
The user interface has support for color themes that are both built-in and user-definable. The canvas transparency tile can also be modified to the user's liking.
Pro Lightweight
The size of the .jar binary is a little less than 1 MB, making the application very lightweight.
Pro Includes a useful text editor
PyxleOS features a basic text editor module that can be used for note-taking or modifying a file that follows encoding standards.
Pro Secure, Java-based cross platform binary
PyxleOS can be used on any OS that runs Java 8 and above.
Pro Free and open source
The download of PyxleOS is free and all source code is available at a public repository at GitHub.
Cons
Con Not available on Windows
PikoPixel is only available for Mac and Linux.
Con Undo/redo unavailable
Undo/redo functions are not available in PyxleOS.
Con Lacks a number of features
Due to it being relatively new software, PyxleOS is somewhat buggy and underfeatured.