When comparing Piskel vs GraphicsGale, the Slant community recommends GraphicsGale for most people. In the question“What are the best pixel art / sprite editors?” GraphicsGale is ranked 5th while Piskel is ranked 7th. The most important reason people chose GraphicsGale is:
The animation tools in GraphicsGale are very easy to work with. Furthermore, the live preview helps clean up the animations in real time without a hitch.
Specs
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Pros
Pro Works in any browser
WPiskel is HTML5-based so it works in any modern browser.
Pro Animation support
Piskel includes onion skinning, exporting to sprite sheets or gifs, defining frame rate, and present live playback.
Pro Sleek interface
It is also easy on the eyes.
Pro Very simple for beginners
Once you get the hang of it its a very powerful tool
Pro Offline versions available
The downloadable version of Piskel (built with node-webkit) is available for Windows, Linux, and Mac OS X.
Pro Easy to use lighten and darken tool
With the click of a button you can create amazing shading.
Pro Enough tools to be powerful
It has enough tools to be powerful, but not too many to put off beginners.
Pro Open source
Piskel is licensed under Apache License, meaning that the user can use the software for any purpose.
Pro Has a straight foreward tile view mode
... so you can instantly see the result while drawing tiles
Pro Powerful animation tools
The animation tools in GraphicsGale are very easy to work with. Furthermore, the live preview helps clean up the animations in real time without a hitch.
Pro Offers a great palette tool
With GraphicsGale, the user can save and load palette, create gradation, and make color uniform.
Pro Free
Graphics Gale used to cost money but recently the program switched over to a free license.
Pro Pretty easy to learn the UI and the tools you have to work with are fantastic
Pro Works really well under Wine
Wine can help emulate Windows on non-Windows systems. You can get Graphics Gale running anywhere Wine can run. See WineHQ for more details.
Cons
Con Lacks a true resizing tool
There doesn't seem to be any decent tool in Piskel for an easy stretch or shrink. The only ways possible is resizing the whole image or importing and image and shrinking it from the export tool.
Con No button for undo
Have to use ctrl+Z.
Con Rotation is limited
Rotation is only made in predefined angles. Does not support variable rotations or mouse based rotation. Does not support rotating selected areas, only frames-layers.
Con Shading by hand
Shading can be difficult.
Con Doesn't work well with drawpads
In the online tool you can't draw lines at all, yet using a graphic tablet, being in the offline version controls are pretty chunky and everytime you start drawing a line, the screen flickers black for a short period of time.
Con Only available on Windows
GraphicsGale is only available on Windows.
Con UI requires a lot of clicking
The UI windows not very nice and requires a lot of clicking. For example mouse wheel is not useable at all to zoom in and out in main window.