When comparing Piskel vs Adobe Animate (formerly Flash Professional), the Slant community recommends Adobe Animate (formerly Flash Professional) for most people. In the question“What are the best 2D animation tools for game development?” Adobe Animate (formerly Flash Professional) is ranked 8th while Piskel is ranked 15th. The most important reason people chose Adobe Animate (formerly Flash Professional) is:
This program has developed AAA TV Series and Movies like Fosters Home for Imaginary Friends and My Little Pony: Friendship is Magic.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Works in any browser
WPiskel is HTML5-based so it works in any modern browser.

Pro Animation support
Piskel includes onion skinning, exporting to sprite sheets or gifs, defining frame rate, and present live playback.
Pro Sleek interface
It is also easy on the eyes.
Pro Very simple for beginners
Once you get the hang of it its a very powerful tool
Pro Offline versions available
The downloadable version of Piskel (built with node-webkit) is available for Windows, Linux, and Mac OS X.
Pro Easy to use lighten and darken tool
With the click of a button you can create amazing shading.
Pro Enough tools to be powerful
It has enough tools to be powerful, but not too many to put off beginners.
Pro Open source
Piskel is licensed under Apache License, meaning that the user can use the software for any purpose.
Pro Has a straight foreward tile view mode
... so you can instantly see the result while drawing tiles

Pro Powerful tool
This program has developed AAA TV Series and Movies like Fosters Home for Imaginary Friends and My Little Pony: Friendship is Magic.
Pro Export to HTML5
Pro Interpolation between frames
Several ways to create animation and special effects: motion tweens, classic tweens.
Pro Create and organize layers
Layers help you organize the artwork in your document. You can draw and edit objects on one layer without affecting objects on another layer.
Pro Bone tool
Bone tool that enables you to link symbols together quickly and easily in a parent/child relationship commonly referred to as inverse kinematics.
Pro Easy to use
Cons
Con Lacks a true resizing tool
There doesn't seem to be any decent tool in Piskel for an easy stretch or shrink. The only ways possible is resizing the whole image or importing and image and shrinking it from the export tool.
Con No button for undo
Have to use ctrl+Z.
Con Rotation is limited
Rotation is only made in predefined angles. Does not support variable rotations or mouse based rotation. Does not support rotating selected areas, only frames-layers.
Con Shading by hand
Shading can be difficult.
Con Doesn't work well with drawpads
In the online tool you can't draw lines at all, yet using a graphic tablet, being in the offline version controls are pretty chunky and everytime you start drawing a line, the screen flickers black for a short period of time.
Con No more support
Adobe ditched AIR which they will EOL at 2020

Con Exspensive
Flash can be priced at $999.99 on the official Abobe store.
