When comparing PyxleOS vs GraphicsGale, the Slant community recommends GraphicsGale for most people. In the question“What are the best pixel art / sprite editors?” GraphicsGale is ranked 5th while PyxleOS is ranked 26th. The most important reason people chose GraphicsGale is:
The animation tools in GraphicsGale are very easy to work with. Furthermore, the live preview helps clean up the animations in real time without a hitch.
Specs
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Pros
Pro Customizable UI
The user interface has support for color themes that are both built-in and user-definable. The canvas transparency tile can also be modified to the user's liking.
Pro Lightweight
The size of the .jar binary is a little less than 1 MB, making the application very lightweight.
Pro Includes a useful text editor
PyxleOS features a basic text editor module that can be used for note-taking or modifying a file that follows encoding standards.
Pro Secure, Java-based cross platform binary
PyxleOS can be used on any OS that runs Java 8 and above.
Pro Free and open source
The download of PyxleOS is free and all source code is available at a public repository at GitHub.
Pro Powerful animation tools
The animation tools in GraphicsGale are very easy to work with. Furthermore, the live preview helps clean up the animations in real time without a hitch.
Pro Offers a great palette tool
With GraphicsGale, the user can save and load palette, create gradation, and make color uniform.
Pro Free
Graphics Gale used to cost money but recently the program switched over to a free license.
Pro Pretty easy to learn the UI and the tools you have to work with are fantastic
Pro Works really well under Wine
Wine can help emulate Windows on non-Windows systems. You can get Graphics Gale running anywhere Wine can run. See WineHQ for more details.
Cons
Con Undo/redo unavailable
Undo/redo functions are not available in PyxleOS.
Con Lacks a number of features
Due to it being relatively new software, PyxleOS is somewhat buggy and underfeatured.
Con Only available on Windows
GraphicsGale is only available on Windows.
Con UI requires a lot of clicking
The UI windows not very nice and requires a lot of clicking. For example mouse wheel is not useable at all to zoom in and out in main window.