When comparing AutoPy vs GNURoot, the Slant community recommends GNURoot for most people. In the question“What are the best ways to run Linux applications on Android?” GNURoot is ranked 11th while AutoPy is ranked 13th. The most important reason people chose GNURoot is:
GNURoot is a completely self-contained app that cleanly uninstalls and doesn't need root permissions.
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Pros
Pro Open source and cross-platform
Pro Support for image processing
Functions for finding colors, and working with bitmaps.
Pro Allows Mouse & Keyboard control
Pro Simple
Made to be used in Python in an intuitive and easy way.
Pro Efficient
It's a thin-wrapper of code written in pure C.
Pro Does not require a rooted phone
GNURoot is a completely self-contained app that cleanly uninstalls and doesn't need root permissions.
Pro Includes a VNC client for GUI apps
Setting it up takes some effort. And 3rd-party VNC client (or X server) apps might have a better user interface than GNURoot's default. These also work, but also take some effort to set up.
Cons
Con Wakelocks on by default
It drains the battery pretty quickly when running.
Con Requires a lot of manual configuration
GNURoot doesn't hold your hand and isn't even documented very well. Getting anything graphical to run takes some doing.