When comparing Desura vs Humble Store, the Slant community recommends Humble Store for most people. In the question“What are the best distribution platforms for an indie desktop game?” Humble Store is ranked 4th while Desura is ranked 7th.
Ranked in these QuestionsQuestion Ranking
Pros
Pro Strong Linux presence
Linux support is a core feature of Desura. All games in the storefront are tagged as to whether or not they will run on Linux.
Pro Alphafunding permits sale of works in progress
Desura calls their early access program "Alphafunding." Games must show a minimum level of development, and must show active development or risk being removed.
Pro Indie Royale bundles can boost sales
Indie Royale is a joint venture of Desura and IndieGames.com which sells bundles of games on a pay-what-you-want basis (but with a minimum price). Most games sold via Indie Royale bundle are Desura titles.
Pro Access to sales data
Pro Just above average revenue split (75/25)
Pro Opportunity for homepage feature of your game with a launch sale after a short “soft-launch” period
Once Humble has had a chance to ensure your game page has all the kinks out, you can be featured by offering a new release sale.
Cons
Con Desura's Parent company filed for bankruptcy
Con No access to customer email addresses
If you want to tell your fans about your new game, too bad unless you've collected it through your game client or somewhere else.