When comparing Unity 2D vs Moho 12, the Slant community recommends Unity 2D for most people. In the question“What are the best 2D skeletal animation tools?” Unity 2D is ranked 5th while Moho 12 is ranked 8th. The most important reason people chose Unity 2D is:
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Built into Unity 4.3+
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Pro Integrates with Mecanim
Mecanim brings state machines and blending to 2D bone animation. The state machine editor allows for designers and programmers to visually create a Finite State Machine (FSM) to control when animations should play. Mecanim also allows for blending so an animation can transition smoothly between two states without the need of in between frames made by an animator.
Pro Sprite Sheet and Bone based animation supported
Both types of 2D animation for game development are supported in Unity’s system and can be used interchangeably in the timeline.
Pro Easily change sprites dynamically
Usually used for character customization, programmers can change any sprite in a bone animation at runtime easily by referencing the bone and loading the new sprite from the resources folder.
Pro Cheaper than Toon Boom and Adobe Products
Cheaper than Toon Boom and Adobe Products. People often complain about the price hike, but the pro version does go on sale, and even the full priced version is less than other insdurty standards on the market.
Pro Good community support
Lots of online forums, Facebook groups, YouTube videos, etc.
Pro It's better than any 2D animation software on the market for vector based animations
It beats Adobe Flash and Toon Boom at vector based animation. It has more features for 2D vector animations with it's integration with 3D mesh and bone rigs. Smart bone rigs create better animtions with less distortions then Toon Boom, and there are no bone rig animation options with Adobe Flash.
Pro Easy to use interface
Quicker to animate and use than other similar products.
Cons
Con Lacks critical features
- Vertices can't be animated, so you can't have ANY organic feel (like... lungs breathing).
- Parent bone can't be animated without affecting the children. This is especially impeding for organic feel, again.
- No option to show & unshow assets (or it is hidden), like for switching weapon on your character for exemple.

Con Poor script interface for texture atlases
Accessing individual sprites within an atlas texture is possible at runtime, but requires use of the Resources folder subsystem.
Con Too expensive
Con Limited support for game engines
In most cases you'll have to export and edit sprite sheets. This will consume memory. Also, FBX file support is limited and not all features will run in Unity. Aside from Unity, there is no support for runtimes for video game engines. Also, many animation features such as vector integrated features will not export to Unity. Spriter, Spine, and Dragon Bones would be better options.
