When comparing Puppet2D vs Uni2D, the Slant community recommends Puppet2D for most people. In the question“What are the best 2D plug-ins for Unity3D?” Puppet2D is ranked 3rd while Uni2D is ranked 6th. The most important reason people chose Puppet2D is:
Instead of having to change sprites to bend legs or other joints mesh deformation changes the mesh shape based on joint weights to bend and move.
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Pros
Pro Mesh Deformation
Instead of having to change sprites to bend legs or other joints mesh deformation changes the mesh shape based on joint weights to bend and move.
Pro Inverse Kinematic bones
Bones will move and rotate reacting to the position of the rest of the skeleton. The animator does not have to animate each part of a joint but rather have it follow realistically. Also can be used for ragdoll effects based on physics.
Pro Built on top of Unity’s animation system
Mecanim and state machines work natively since Puppet2D builds on top of Unity’s built in animation system.
Cons
Con Forced editor scaling causes problems
Puppet2D adjust the scaling of bones in the editor for display purposes, which results in unintended behavior if other objects use a bone as a parent.