When comparing uScript + Unity3D vs TIC-80, the Slant community recommends TIC-80 for most people. In the question“What are the best 2D game engines?” TIC-80 is ranked 49th while uScript + Unity3D is ranked 97th. The most important reason people chose TIC-80 is:
The app contains tools for coding, sprite editing, map editing, sfx and music editing.
Specs
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Pros
Pro Automatically generates nodes for third-party script assets
uScript's nodes are a visual representation of actual code blocks, and it takes advantage of C#'s reflection capabilities to automatically create nodes for any scripts it finds in your project, regardless of the source. This makes it inherently compatible with pretty much everything.
Custom nodes can also be created by hand, for cases where the automatically created ones contain more elements than they actually need.
Pro Versatile flow diagram script model
Modeled after UDK's Kismet (the predecessor to UE4's Blueprint), uScript's scripts resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.
Pro Generates C# source code
Nodes are translated directly to C# files in your project. This is great for learning to code, and also for advanced users who can use uScript for fast prototyping and then further optimize the scripts if necessary.
Pro All tools in one place
The app contains tools for coding, sprite editing, map editing, sfx and music editing.
Pro Free
Free version already includes most features but a paid version is available.
Pro Retro-styled and restricted environment
Pixelated Software with a good retro style.
Pro Many Scripting languages' supported
Use awesome scripting languages like: Lua, Wren, Moonscript, JS, Ruby, etc.
Pro Export
Exports easily to Windows, Windows-XP, mac, Linux and HTML.
Pro Noob underdog
You can imagine this engine Shiva Lua scripting language making 2d side scrolling Megaman style games a Bandai trademark.
Cons
Con Not that easy to use
It's a lot more complicated compared to something like Playmaker. Same tasks take a lot more time.