When comparing Guayadeque vs Lollypop, the Slant community recommends Lollypop for most people. In the question“What are the best audio players for UNIX-like systems?” Lollypop is ranked 12th while Guayadeque is ranked 17th. The most important reason people chose Lollypop is:
You can view all the albums you have in one long list. Clicking on one of them will bring a popup at the bottom of the screen where you will see a list of all the songs on that album.
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Pros
Pro Starts fast
Most other players start rather slowly. This one is written in C++, and the end result is excellent speed.
Pro Doesn't use much memory
Once installed, Guyadeque only uses about 15 MBs.
Pro Well-implemented auto playlist
After music has finished playing, Guadayeque will play a similar type of music.
Pro Handles large music databases very well
Pro Smart play
It automatically make a playlist song-by-song you hear from your music file. It finds similar songs. So, as you listen to a song an endless playlist with similar songs is about to happen..
Pro Lots of niceties / options / integration
Last.fm shows your profile in the software and also displays info about the artist.
Lyrics are downloaded automatically when you want to see them.
Cross-fading between songs keeps music constantly coming, which is very important when using music to block out ambient sounds.
VU (volume unit) Meters give you something to look at while the music is playing.
Pro Clean appearance
Guayadeque has a clean yet customizable appearance.
Pro Super intuitive way of organizing and browsing albums and artists
You can view all the albums you have in one long list. Clicking on one of them will bring a popup at the bottom of the screen where you will see a list of all the songs on that album.
Pro Works fast and reliably
Pro Super flexible layout
The latest version has a good full-screen layout and is very responsive. Goes very smoothly from full screen to minimal player (also being a GTK+ app).
Pro Integrates with the MPRIS sound menu
This applies for most players in the "Linux world", but not for all. Therefore I consider it worth mentioning.
Pro Huge development
There is constant improvements, librem and gnome3 is possibly the future.

Pro Cloud music
Lollypop allow you to play music from the web (iTunes charts and search from Spotify).
Pro Integrates well with many desktop environments
One example being the conditional use of client side decorations (a.k.a. header bars) depending on the currently active desktop environment.
Pro Good party mode
Pro Clean, light and works very well.
The only one that can play a lot of files without to stop.
Pro Queue option lets you change what's playing on the fly
You can add songs to a queue, and then re-order or remove songs as you please. It works similarly to a temporary playlist.
Pro Online radio integration
The newest version features a nice interface for adding, browsing, and playing online radio stations. This gives you access to more music than you would normally have, which can help expand your music library for free.
Cons
Con Development seems to stall since 2016
Con Sidebar lists multiple artists as one artist
A song with multiple artists labeled like "Artist 1; Artist 2; Artist 3" will not be displayed under all three artists, but rather under an artist labeled as "Artist 1; Artist 2; Artist 3." This makes actions as simple as queuing up an album with multiple artists a huge pain.
Con Songs with differing artists in an album are displayed as separate albums
Suppose Album 1 by Album Artist A has a lot of songs by Artist A, with one song that features Artist B. Album 1 will get fractured across different artists in the sidebar.
Con Interface is too busy
There's a lot shown on each of Guayeque's screens, and the more important buttons (play/pause and skip buttons) are small and hidden in the top left corner. Most users use music players in the background, meaning they will be switching back and forth with whatever else they're doing. As such, having larger buttons in a more prime location would be preferable.
Con Sometimes freezes and crashes
This can happen if you change some settings i.e. add or remove tabs etc.
Con GTK App
Its a GTK app so integration in other desktops is terrible it also uses GNOMEs ClientSideDecorations so it will break many window managers.
Con No equalizer
Lollypop still does not have an equalizer.
Con Good party mode
Con No In-App Volume Control (0.9.242)
It has no in-app volume control, it has to be managed through system 'Sound control/Applications'

Con Requires a well organized music collection
Lollypop will be a pain to use if music is badly tagged. The setup is a one time thing, but it can be a pain to organize a large library.
