When comparing Pandemic vs Santorini, the Slant community recommends Pandemic for most people. In the question“What are the best couples board games?” Pandemic is ranked 1st while Santorini is ranked 7th. The most important reason people chose Pandemic is:
When it was first released, Pandemic's co-op gameplay was a pretty unique aspect to boardgames and made for a different and fun experience where either all players won or lost as a team. As the board gaming hobby has grown over the years, fully co-operative games have become an entire genre, and yet Pandemic remains one of the defining examples of the style. With a base game that is consistently difficult--even for veteran players--and an engaging and interesting theme to draw players in, this is a game where working together to achieve victory is almost an art form.
Specs
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Pros
Pro One of the first games to implement full co-op gameplay, Pandemic remains one of the defining examples of the genre
When it was first released, Pandemic's co-op gameplay was a pretty unique aspect to boardgames and made for a different and fun experience where either all players won or lost as a team. As the board gaming hobby has grown over the years, fully co-operative games have become an entire genre, and yet Pandemic remains one of the defining examples of the style. With a base game that is consistently difficult--even for veteran players--and an engaging and interesting theme to draw players in, this is a game where working together to achieve victory is almost an art form.
Pro Lots of replayability thanks to each playthrough being unique
With multiple player roles (Pilot, Scientist, Doctor, etc) to choose from and the card draw that infects areas at random, each playthrough is an entirely different experience. Pandemic also has multiple expansions adding more player roles and even a traitor mechanic which can turn the game from fully co-op to 1 vs many, adding an additional challenge for the good guys to overcome.
Pro Easy to learn but still provides a challenge
Learning the rules doesn't take long at all, and within a few rounds, most players will be able to pick up what's going on. Even though the general game flow and rules are quick to understand, there is still plenty of nuances to gameplay, little tricks you'll be learning along the way, and plenty of different roles to choose from which allow room for in-depth strategies.
Pro Creates a sense of urgency thanks to the Infection Deck
One of Pandemic's greatest mechanisms is the way the Infection Deck is managed. Each turn players reveal a number of city cards from this deck equal to the current infection level (2-4), this determines where new infections will appear. Players also draw 2 cards each turn from the Player Deck, which has a variable number of Epidemic Cards mixed in based on the difficulty level.
The brilliance of the infection deck is how it interacts with Epidemic cards; when one is drawn from the player deck the Infection Deck's discard pile is shuffled, and then placed on top of the current Infection Deck, making it more likely that cities that have previously had outbreaks will have them again.
This creates a very real sense of urgency as the first draw after an Epidemic Card can often result in outbreaks and a rapidly accelerating spread of diseases.
Pro The different editions/expansions stay true to the Pandemic experience yet offer something fresh each time
For example, in Pandemic Iberia, your movement is much more limited therefore you have to invest in building railways and the diseases cannot be cured, only researched. They will continue to infect even after being researched. Each expansion is easy to pick up and play as it offers something new while keeping the base game familiar.
Pro Easy to understand yet deep gameplay
The basic premise of Santorini is simple; players use their workers to move around the map, build towers, and attempt to be the first to ascend to the 3rd level of one of these towers. However, much like its more serious counterpart, Chess, Santorini has an astounding amount of depth as players move to block and trap one another all while positioning for that one winning move. Adding in the God Powers further opens up the options for interesting gameplay and in-depth strategy as players make use of one of these unique cards to give their workers special powers like building twice, moving opponents, or even removing buildings.
Pro A ton of replayability
The base game of Santorini will almost always play out differently as players try different techniques and strategies for besting their opponent - different starting points, different routes, trying to build up yourself or trying to disturb the opponent. However, the game gets really interesting with the introduction of God Power cards.
Adding in the 30 God Powers from the base set adds a whole new layer of variable conditions for each game and allow for a huge variety of potential combinations. Each God Card adds some sort of different rule to the game, and you must follow this instruction for the whole game. Otherwise, you lose. Some God Cards give you specialized win conditions, some allow the removing of opposing workers, and others make you specifically alternate your movement patterns. For example, the Apollo card allows a player to swap positions with the opponent.
If that isn't enough, the Golden Fleece expansion adds another 15 God Cards, 10 Hero Cards, and an entirely new variant to the game.
Pro Excellent component quality
From the raised, three-dimensional board to the high quality building blocks, all of the components in Santorini are top-notch. The tarot sized cards are beautifully illustrated and contain easy to recognize iconography, the main game board is made up of 3 parts that raise it up off the table and give it an excellent sense of scale, and the building pieces are fantastically modeled so that they stack together easily and look great as the city is built from the ground up!
Cons
Con Can suffer from Alpha-gamer / quarterbacking issues
Due to the nature of co-op games like Pandemic, a strong willed or loud player can end up dictating everyone else's turns for them, especially in situations where there are clearly better decisions to be made. This can lead some people to feel like they aren't actually 'playing' so much as being told what to do.
Con Won't appeal to competitive PvP players
Everyone works together in Pandemic, so there is no dominating or crushing your opponents in this game. This may not appeal to some competitive gamers who would prefer to play games that allow them to best other players.
Con Difficult
Pandemic is a pretty difficult game, there will be a lot of losses compared to wins. Though when there is a win it does feel righteously earned.