When comparing Microlite20 Purest Essence vs Shadowrun, the Slant community recommends Shadowrun for most people. In the question“What are the best tabletop RPGs?” Shadowrun is ranked 23rd while Microlite20 Purest Essence is ranked 54th.
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Pros
Pro Easy to start
If you are looking for a game like DnD, but much easier - try Microlite20 Pures Essence with Ultimate Fantasy supplement.
Pro Rules will be familiar to any veteran D&D player
As Microlite20 is a stripped down version of the d20 SRD with the same classes, races, items and abilities, it will be easy to understand by anyone that has previously played a D&D game. Especially D&D 3.x.
Pro Compatible with d20 SRD
Any material written for the d20 system can be used with the Microlite20 system. All creatures, items, monsters, spells, etc from any d20 SRD licensed resource are compatible with the Microlite20 system.
Pro Clear writing
The writing is very terse and to the point. There's very little in terms of fluff. As such the rules are easy to comprehend and reference.
Pro Simple rules allow easy customization
m20 remains compatible with the d20 SRD, but rules are lite enough that adding modifications to the system is trivially simple.
Pro In-depth character creation
Cons
Con Combat can potentially get stale
Due to the fact that combat is simplified to just 3 variables (AC, HP and attacks) a less experienced DM runs the risk of creating repetitive combat.