When comparing Open d6 vs Microlite20 Purest Essence, the Slant community recommends Open d6 for most people. In the question“What are the best tabletop RPGs?” Open d6 is ranked 22nd while Microlite20 Purest Essence is ranked 54th. The most important reason people chose Open d6 is:
Open d6 includes rulebooks for Fantasy, Adventure and Space settings.
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Pros
Pro Includes rulebooks covering the more common genres
Open d6 includes rulebooks for Fantasy, Adventure and Space settings.
Pro No special dice required
The game can be played with common six-sided dice.
Pro A simplified variant, called Mini Six, is available
Mini Six is a fan-made variant of Open d6 that aims to be a distilled version of the Open d6 system.
Pro There are theme-related books available to start various types of games
D6 Space is West End Games old "Star Wars D6" game with all of the licensed Star Wars names removed. It's a stand alone complete game.
D6 Fantasy is a standalone ruleset for running a D&D type game with the D6 system.
D6 Adventure is a standalone ruleset for using the D6 system in a Wild West, spies, or modern adventure game.
All three have supplement books (Spaceship design, magic, aliens, etc).
Pro Each rulebook has a good introductory section
Pro Easy to start
If you are looking for a game like DnD, but much easier - try Microlite20 Pures Essence with Ultimate Fantasy supplement.
Pro Rules will be familiar to any veteran D&D player
As Microlite20 is a stripped down version of the d20 SRD with the same classes, races, items and abilities, it will be easy to understand by anyone that has previously played a D&D game. Especially D&D 3.x.
Pro Compatible with d20 SRD
Any material written for the d20 system can be used with the Microlite20 system. All creatures, items, monsters, spells, etc from any d20 SRD licensed resource are compatible with the Microlite20 system.
Pro Clear writing
The writing is very terse and to the point. There's very little in terms of fluff. As such the rules are easy to comprehend and reference.
Pro Simple rules allow easy customization
m20 remains compatible with the d20 SRD, but rules are lite enough that adding modifications to the system is trivially simple.
Cons
Con Complicated magic system
Con Combat can potentially get stale
Due to the fact that combat is simplified to just 3 variables (AC, HP and attacks) a less experienced DM runs the risk of creating repetitive combat.