When comparing Keynote vs Framer Studio, the Slant community recommends Framer Studio for most people. In the question“What are the best tools for prototyping mobile interactions/animations?” Framer Studio is ranked 1st while Keynote is ranked 7th. The most important reason people chose Framer Studio is:
Framer uses coffeescript for defining animations. CoffeeScript has a low learning curve and as such it can be learned easily even by non-programmers.
Specs
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Pros
Pro Imports nearly every type of asset
Can import all kinds of assets (images, videos, PDFs, sounds) into mockup without hassle.
Pro Animations and transitions
Keynote currently is one of the very few tools that supports animation of elements and transition of views without programming.
Pro Text Styles makes it easy to create typography systems
Pro Smart Snaps
Keynote has alignment grids (aka snap to grid feature) that snaps to end, midpoints, baselines etc of objects and grids. They are super useful when you want to follow a structured layout for your wireframe.
Pro CoffeeScript integration to define animations
Framer uses coffeescript for defining animations. CoffeeScript has a low learning curve and as such it can be learned easily even by non-programmers.
Pro Multiple device support
Framer supports animation and interaction prototyping for multiple devices, ranging from desktop apps to web apps and mobile platforms. There are already 8 pre-installed devices to choose from, or developers can create their own setup quickly.
Pro Photoshop & Sketch integration
Framer is integrated with Framer Generator, which allows developers to import layers directly from Adobe Photoshop and/or Sketch.
Pro Instant visual feedback
Framer Studio offers and instant preview of the animation that is currently being made.
Cons
Con Only available on Mac and it's file are not compatible with Microsoft Windows
Con Coding required
Framer Studio uses CoffeeScript for prototyping the UI of an app. This can be a problem for designers who don't know CoffeeScript since they would be forced to learn a new programming language in order to use Framer.
Con Mac only
Framer Studio is only supported for Mac. There is no version for Windows or Linux.