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PSequel is currently free to use.
Pro Fast, native UI
The UI is clean, simple and elegant
Con No way to save files
You cannot save a file. Makes it way to easy to lose work.
Con Still in development, lack of some features
You can't add table with GUI yet, you need to write a statement
Con Closed source
PSequel is currently closed source and the developer has stated there is no plans to open source it in the near future.