The Kinesis Advantage is an ergonomic keyboard which is shaped differently to be more comfortable and prevent injuries which can be caused by finger strain.
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Pro Optimised to be very ergonomic
This keyboard is sculpted to fit the curvature of your hand more naturally than regular flat boards. This helps reduce repetitive strain injury which can happen to typists.
Pro Clusters of keys under each thumb means less far reaches
Moving multiple keys under the thumbs lets you keep the rest of your hands still, and helps prevent far reaching. For example, the backspace key on a regular keyboard is way in the top right corner, while on the Kinesis Advantage it's under the left thumb - to hit the backspace button you aren't need to move your thumb while on regular keyboards you need to move your whole right hand and stretch your pinky to reach it.
Pro Saves Your Hands from RSI
The Kinesis Contour Keyboard has numerous ergonomic advantages over a keyboard with a standard layout. Some of these differences are obvious and some are subtle, but they are synergistic and result in a typing experience that places far less stress on the hands. Learning a tweaked keyboard layout is a small price to pay to avoid RSI (repetitive strain injury).
Pro The Large, raised palm rests are very comfortable
Pro Keys are vertically aligned in straight columns
One of its best features is that the keys are vertically aligned in straight columns, so that you're not constantly exercising the muscles to move your fingers slightly to the left or right. It makes a huge difference.
Pro Handles Mac, Windows & Linux
Pro Very easy to learn
The diagonal layout made it possible that I finally learned touch-typing, after 20 years of keyboard use. And it took only about 10 minutes! I do mean 10 minutes. This only included the letter keys, not symbols numbers etc., and I was slow. After two days I was around my old speed, and after about 1 month I knew all keys.
Pro Thumbs do not have to knock against each other over the spacebar, like with other keyboards
Con Can be a bit flakey at times
The downside of the keyboard is that it can be a bit flakey at times. The biggest problem is that the up-event for a key occasionally gets lost and then some key will auto-repeat until you press it again. Or even worse, it's a key that has no visible effect like an Alt key, and then you have to figure out which key it is that is in the virtual down position, and press it again. It has had this same problem for the last 20 years. You learn to live with it for the sake of your hands.
Con It's unique design requires a learning curve to use
The keys are in different positions than on a regular flat board - the Q key is directly on top (in-line) with the A key instead of being offset. Using your thumbs to hit the buttons on the bottom will take time to get used to as well.
Also, if you have poor typing skills (for example you hit the Y key with your left index finger) some keys may be out of reach of where you're used to finding them. Then again, if you are looking to spend $250+ on a keyboard hopefully you are using proper typing position.
Con No standard function keys
The functions keys are not build with the same technology than the other keys. If you intend to use them a lot like with an IDE, these keys will feel not very natural and ergonomic.