Ranked in these QuestionsQuestion Ranking
Pro Lets you create beautiful presentations that flow well
Prezi helps you create presentations that tell a story. The UI lets you create a storyboard for the presentation so it's really easy to design the big picture for the presentation and then drill down to the individual "slides".
Pro The Storyboard UI makes it easier to think through presentations
Instead of being constrained by individual slides, Prezi lets you input all the various text & media you want to cover and then organise it into a logical flow later on.
Pro Easy to collaborate with co-workers/friends
Another benefit of it being a web-app is how simple it is to collaborate on presentations.
Pro Cross-platform with sync
There is a fully featured web-app as well as apps for Windows, Mac & iOS (iPhone & iPad). All the files sync across the platforms platforms so you don't need to worry about managing files etc.
Con Requires Flash player
Prezi requires Flash Player, so it will not run in a browser on mobile devices. There are apps for mobile, but only the iPad version allows editing.
Con Online only
This presentation application is only available through a browser, with the data hosted on Prezi servers, with all the obvious privacy concerns it induces.
Con Might run slow
On lower end systems it might be a little too slow, so you have to take into account what systems are you planning to present on.
Con The transitions are a distraction from your content.
Prezi encourages you to use gimmicky, distracting transitions.