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Pros
Pro No installation required
HexEdit.js is web-based. If you find yourself working from someone else's machine or in a web cafe this is a useful backup option, as you can access it from anywhere without installing anything, and run it regardless of that machine's OS.
Cons
Con Depends on having a stable Internet connection
Since HexEd.it is only available online, a poor Internet connection can make this tool unusable.