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Org-mode has some basic spreadsheet functionality. Other than auto-formatting ASCII tables (a notoriously annoying problem), it also has support for LISP-like syntax to define equations or any other functionality that can be achieved through spreadsheets. See More
Customizations can be made to a wide range of Emacs' functions through a Lisp dialect (Emacs Lisp). A robust list of existing Lisp extensions include the practical (git integration, syntax highlighting, etc) to the utilitarian (calculators, calendars) to the sublime (chess, Eliza). See More
Most IDEs require you to separately run Python to see the output of a particular piece of code. By contrast, Jupyter Notebook can evaluate Python statements inline, giving you the immediate feedback of interactive use of the interpreter while keeping your changes saved. See More
Jupyter Notebook, formerly known as ipython, used to be specific to Python; however, in recent iterations, it has become capable of general purpose usage for any programming language. Thus it is possible to use this and have a consistent developer workflow, regardless of language. See More
Since Jupyter Notebook really requires two programs (the server and your browser) getting things setup in a way that works for you is a little more complex than for an ordinary IDE. For example, if you run the server and edit on the same machine, creating a little wrapper script that starts the server and then launches the browser pointing to it and gives an icon to this script is a small amount of setup but is more involved than a simple installer for other IDEs. Likewise, if you do remote development, creating a URL that will lazily spawn the Jupyter Notebook server and then turn it down when it is no longer in use is also a little bit of work to setup. See More