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This is the easiest of them all to get up and running. There are tons of options too in case you want to get fancy. See More
Difficult to do anything with other than a basic install. See More
Have used Visual Studio Installer projects, InstallShield Express, InstallShield, and WiX. I prefer WiX. See More
A lot of things are way harder than they have to be, which makes it worse than a zip and a script. For example it can't remember user choices for an installation and you have to use a hack (store information about it in registry) to retrieve them for repair. Also since it is not a script but "declarative" it is way harder to debug it. It can't nativly embed other msi files, you have to use an extension which you can't customize. See More