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While Bottle is a great framework for building small applications (generally less than 1000 lines of code), it starts getting very hard to manage your application if you want to go even a bit larger than that. The fact that it follows a single-file distribution model and that it's missing something like Flask's blueprints only make this problem worse. See More
I have migrated my flask application to Falcon in 3hours. Performance improves a lot. See More
Because it's basically a framework for building real-time applications it has great support for things like WebScokets and uses non-blocking I/O. But it lacks in features that are used to build general-purpose websites like blogs, e-commerce sites, web portals etc... For example it lacks ORM integration (at least out of the box) and it doesn't have a very powerful template engine. See More
Talking to database is a pretty common thing for a web application to do. Larger frameworks know this, and cover it in some detail by the end of the tutorial. In contrast, the Klein documentation is currently silent on this topic, leaving the issue of how to do database queries in a way that won't block your event-driven code entirely up to you. See More
The fact that a Klein server is event-driven and non-blocking means that it can start handling a new request while previous requests are still open. This lets you serve more requests from a single process, meaning running multiple servers is now an option to be explored when your site makes it big, rather than a necessity for responsiveness under even modest loads. Multiple requests per process also gives you flexibility to do things that would be impractical in WSGI-based alternatives like Flask or Bottle, such as keeping a connection to the browser open to send it chat messages or game updates in a Server Sent Event stream. See More