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Org-mode has some basic spreadsheet functionality. Other than auto-formatting ASCII tables (a notoriously annoying problem), it also has support for LISP-like syntax to define equations or any other functionality that can be achieved through spreadsheets. See More
The whole reason that TeX -- and, by extension, LaTeX -- exists is to give people an easy way (well, for some value of "easy") to produce high-quality documents with properly laid out mathematical expressions and text in them. As long as you know the language (or have a reference sheet handy), you can include mathematical expressions in your document with little to no extra effort needed on your part. See More
The Asciidoc format is not as popular/widely used as Markdown. Notwithstanding the foregoing, Asciidoc is used for some of the following projects: O'Reilly and Maker Press NFJS, the magazine other examples: http://asciidoctor.org/docs/what-is-asciidoc/#who-s-using-asciidoc See More
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