Pro Tons of customization
Mutations are one of the biggest parts of Caves of Qud. Want to be a two-headed beguiling spider-thing? A four-armed flying plant-man? You can. There's also lots of armor, weapons, and equipment, which can be found enchanted, as well as a bunch of "spells" (mental mutations) and skills.
Pro Interesting and original setting
The game is set in a post-apocalyptic world that feels truly unique. Caves of Qud's world is like no other, and everything from the creatures/characters you'll encounter, to the items you'll find, and the locations you'll discover is different from what you would find in most rogue-likes.
Con Can be difficult to get started
The beginning of the game explains little, depending on what attributes you put points into in character creation will have a high level of impact at the start of the game. This is not explained to the player, so if you do not put 18 points into "toughness" without having a very particular build in mind that will have some way of dodging or avoiding attacks, the result will just be plenty of death with little advancement.