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Updated
The Camelback Quick Grip bottle is designed for runners. The sleeve allows you to hold it comfortably in your hand while running, and it also has several pockets to put keys or gels in. It's best for short/medium distance runs, since your hand will get tired after a while. It holds 21 ounces of water, and will keep it cool for substantially longer than non-insulated bottles. The sleeve has reflective material all over it for running in the dark.
Specs
Pros
Pro Does not leak
You don't have to worry about getting wet with this bottle, since it has a valve that keeps water from leaking out even when being swung around (as you swing your hands when running). To take a sip, just squeeze the bottle and the valve opens to let water pass through. For times when you are not using it, you can turn the valve to a locked position to be absolutely sure it won't leak in case it tips over or when you're holding it in your bag.
Pro Easy to run with
The Camelbak Quick Grip is lightweight, and holds more water than other handheld bottles, which makes for a good balance between the amount of weight you need to carry and the amount of water you can take with you in a single bottle. Many cheaper handheld bottles are also smaller, so you'd have to refill them more often, or plant water bottles along your route thereby interrupting your run more often.
Cons
Con Hard to find the perfect hand position
Most of your palm will be snug in the sleeve, but you might have to fidget for a while until you find a comfortable position for your thumb. There are indents on the bottle, supposedly for thumb placement, but it still takes some getting used to.