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Pro Easy to reuse components
Pro Server side rendering
React can render it's components and data server side, then it sends those components as HTML to the browser.
This ensures faster initial loading time and SEO friendliness out of the box, since it's indexed as any other static website by search engines.
Pro One-way data flow
React's one-way data binding (or one-way data flow) means that it's easy to see where and how your UI is updated and where you need to make changes. It's also very easy to keep everything modular, fast and well-organized.
Pro Virtual DOM support
Instead of relying on the DOM, React implements a virtual DOM from scratch, allowing it to calculate precisely what needs to be patched during the next screen refresh. This is orders of magnitude faster than fiddling with the DOM itself.
Pro Can be used with different libraries
Pro Functional programming style leads to less buggy UIs
Pro Good debugging tools
React has an official Chrome Extension which is used as a developing and debugging tool. It can be used to quickly and painlessly debug your application or view the whole application structure as it's rendered.
Pro Template engine independent
React provides a template engine (JSX) which is easy to use. But it's not mandatory.
Pro Easy to write tests
Pro Supported by Facebook and Instagram
React is built by Facebook engineers initially to be used only for their inner projects especially to solve the problem of building large complex applications with constantly changing data.
Pro Flux architecture pattern
Flux is a platform agnostic pattern which can technically be used with any application or programming language.
One of Flux' main features is that it enforces uni-directional data flow which means that views do not change the data directly.
With React this is useful because this way it's easier to understand an application as it starts getting more complicated. By having two-way data binding, lead to unpredictable changes, where changing one model's data would end up updating another model. By using the Flux architecture, this can be avoided.
Pro Extensive SVG support
Since React v0.15, SVG is fully supported. React supports all SVG attributes that are recognized by today's browsers.
Pro Supported by ClojureScript libraries
Reagent, Om, Rum, etc.
Pro Keep control over your app's logic
React is just a view library, so you still have (almost) full control over how you app behaves.
Pro Tested on Facebook itself
React is used on one of the most visited websites on the planet, Facebook. With stellar results and with millions of people experiencing it every day.
Pro Great browser support
CanJS supports all modern browsers and IE9+.
Pro CanJS can be used with any other library
CanJS is a collection of individual libraries, each separately available as npm packages. It's easy to use just what you need.
Pro Real time support
CanJS's model layer (can-connect), support real-time updates to lists without adding any additional code.
Con Heavy on memory
React's virtual DOM is fast, but it requires storing elements in the virtual and real DOM increasing memory usage for the page. This can be a real problem for single-page webapps designed to be left running in the background.
Con Not a complete solution
React does not do everything for the developer, it's merely a tool for building the UI of a web app. It does not have support for routing or models, at least not out of the box. While some missing features can be added through libraries, to start using React and use it in production, you still would need to have experience, or at least a good grasp on what the best libraries to use would be.
Con Large file size
react.min.js is 145.5KB in size. It's much larger than some other libraries that offer roughly the same features and it's almost the same size as some MV* frameworks such as Angular or Ember that offer more features out of the box.
Although, it should be mentioned that sometimes having a smaller library may force developers to reinvent the wheel and write inefficient implementations on features that React already has. Ending up with a larger application that's harder to maintain and/or that has bad performance.
Con You have to learn a new syntax
Requires to learn a custom syntax, JSX that has some gotchas and introduce complexity, a steeper learning curve, and incompatibility with other tools.
Though you can opt out from JSX and use vanilla JS instead. But that is not recommended since it adds a lot of unneeded complexity which JSX tries to avoid.
Con No support for legacy browsers
React has recently dropped support for Internet Explorer 8. While the library may still work on IE8, issues that affect only IE8 will not be prioritized and/or solved.