When comparing Buildbox vs Ren'Py, the Slant community recommends Ren'Py for most people. In the question“What are the best 2D game engines?” Ren'Py is ranked 39th while Buildbox is ranked 51st. The most important reason people chose Ren'Py is:
Available on Windows, Linux, OSX, iOS and Android.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Drag - and - drop editor
Drag - and - drop editor without writing any line of code.
Pro Easy to learn
Buildbox is a drag and drop engine, making it easy for beginners to pick up. There are many tutorials available to help get you started.
Pro Has many game templates
Buildbox has 20+ different game templates including templates for platformers, racing games and Flappy Bird clones.
Pro Built-in support for ads
You can add banner and interstitial ads from multiple ad networks, including AdMob, RevMob, Facebook. They can work with Amazon's, Microsoft's, Google's and Apple's app stores.
Pro Develop once publish everywhere
Exporting iOS/Android/macOS/Windows/Steam/Amazon
Pro Cross-platform
Pro Cross-platform
Available on Windows, Linux, OSX, iOS and Android.
Pro Active and friendly community
Pro Reasonably good at creating puzzle and point-and-click games
Cons
Con Incredibly Expensive
$99/mo for full functionality probably makes this the least accessible piece of game development software in regards to price, all with a very limiting feature set.
Con You are restricted by it's limitations
For example, you can only make certain kind of games.
Con Not very powerful
You will be limited to using templates to build games.
Con Subscription Model
The two more reasonable price points limit the functionality of a software already far less powerful than many more cost effective alternatives.

Con Very expensive
Buildbox has a 15-day trial version, after that a $2675 license to use it must be bought.
Con Stability Issues
The software has stability issues on Windows, with the preview window causing program crashes when simple functionality is added.
Con Not for every genre
While technically capable of creating 2D games in any genre, Ren'Py excels in creating visual novels and has a reasonable feature set for creating puzzle and point-and-click games. Other genres are best tackled by other engines.
Con Outdated Documentation and official built-in tutorials
Unfortunately, you will have to hunt relevant info on how Ren'py script works. The Ren'Py dev has the working tutorials on his Patreon, other than that you might as well just code in Python.
Con Requires knowledge of Python to use
