When comparing Ren'Py vs Wave, the Slant community recommends Wave for most people. In the question“What are the best 2D game engines?” Wave is ranked 33rd while Ren'Py is ranked 39th. The most important reason people chose Wave is:
In addition to online [API documentation](http://waveengine.net/Engine/Documentation), the Wave Engine team provides [tutorials](http://www.indiedb.com/engines/wave-engine/tutorials) via IndieDB, plus [sample projects](https://github.com/WaveEngine/Samples) and "[QuickStarters](https://github.com/WaveEngine/QuickStarters)" via GitHub.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Cross-platform
Available on Windows, Linux, OSX, iOS and Android.
Pro Active and friendly community
Pro Reasonably good at creating puzzle and point-and-click games

Pro Extensive learning material
In addition to online API documentation, the Wave Engine team provides tutorials via IndieDB, plus sample projects and "QuickStarters" via GitHub.

Pro Supports coding in C#, F# and Visual Basic
Wave Engine explicitly supports all three core .Net Platform languages.

Pro Oculus Rift support
The Wave Engine team provides an official, open-source Oculus Rift extension via GitHub.

Pro Many components are open source
Several core components and official extensions of the Wave Engine are publicly hosted on GitHub.
Cons
Con Not for every genre
While technically capable of creating 2D games in any genre, Ren'Py excels in creating visual novels and has a reasonable feature set for creating puzzle and point-and-click games. Other genres are best tackled by other engines.
Con Outdated Documentation and official built-in tutorials
Unfortunately, you will have to hunt relevant info on how Ren'py script works. The Ren'Py dev has the working tutorials on his Patreon, other than that you might as well just code in Python.
Con Requires knowledge of Python to use

Con Mandatory splash screen
Games and applications made with Wave Engine must display a splash screen advertising it. No splash-free license option is available.
Con Not many tutorials available
Con Outdated UI
The UI looks like it is from Windows XP days. A refresh is much needed.
