When comparing Nix vs Fedora, the Slant community recommends Fedora for most people. In the question“What are the best Linux distributions for desktops?” Fedora is ranked 12th while Nix is ranked 64th. The most important reason people chose Fedora is:
Fedora is backed by RedHat, the 2nd biggest Linux kernel contributor in the world. Using a distribution made by RedHat means that it will be fine-tuned to work as efficiently as possible since it's made by the same people who work extensively on the kernel and know its ins and outs.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro No side effects when building packages
Nix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Isolated development environments
Nix allows the creation of project-specific shell and build environments which are isolated from the rest of the system. These environments are defined declaratively to ensure reproducibility.
Pro Can replace docker in some places
Pro Can use multiple versions of the same package
Because of the functional approach it takes, Nix makes it easy for systems to use multiple versions of the same package simultaneously, and ensure that updating or removing a package can't break other packages.
Pro The configuration works on "All machines"
No more of the traditional: "it works on my machine". When it says reproducible, this is the real deal.
Pro Backed by one of the biggest Linux kernel contributors
Fedora is backed by RedHat, the 2nd biggest Linux kernel contributor in the world. Using a distribution made by RedHat means that it will be fine-tuned to work as efficiently as possible since it's made by the same people who work extensively on the kernel and know its ins and outs.

Pro Integration with GNOME
It perhaps has the best integration with GNOME (GNOME software works out of the box).
Pro Focuses on innovation
By using bleeding edge software, Fedora allows for innovation to take place by testing out things which other distros are not willing to try due to fears of having instability issues.
Pro Fast and stable updates
Pro Frees developers from some backward compatibility restraints
Fedora has a relatively short life cycle: version X is supported only until 1 month after version X+2 and with approximately 6 months between versions this means that a version of Fedora is supported for approximately 13 months. This promotes leading-edge software because it frees developers from some backward compatibility restraints.
Pro Strong commitment to free software philosophy
Pro Fast performance
Pro Very good integration with Flatpak and Snap Packages
Pro Huge array of binary packages ready to install
Pro Can still be installed in a bad sector on the hard disk
Pro Linus Torvalds' distro of choice
Pro Create user after the installation
Very good for selling PC‘s with Fedora.
Pro Frequent updates to latest versions of software, so quick security and other bug fixes
Latest version software often means quick bug fixes, more useful features. For example, for a daily user of TeX, the latest TeX distro is a must. It's also useful to be able to use recent external hardware such as USB Wi-Fi dongles or printers.
Pro Minimalist GNOME
Fedora Workshop does not come with bloatware. It is a minimal GNOME installation, which makes it very simple and nice to use out of the box.
Pro The best choice for sysAdmin and developers
Nearly flawless, perfect performance and consistency with development and operational software.
Cons
Con Does not work well for services on non-NixOS systems
When using Nix with anything other than NixOS you can run into difficulties with trying to start up services. For example, you can install docker with Nix, but it won't integrate with the host system's systemd leaving you to handcraft awkward workarounds in order to start the background service that docker requires. This seems like a critical flaw when using Nix on anything that is not NixOS, and it's unfortunate because this affects many of the packages many users would be most interested in using Nix to handle.
Con Steep learning curve
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Nix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions. Especially in Debian/Ubuntu it can cause severe problems where the upgrade process blocks and the user needs to resolve the 3-way merge.
Con Feels slightly over-complicated
Con Too many changes to upstream packages leading to a "Fedora way" of doing things
Linux should be Linux, but Fedora is constantly introducing breakage and changes which move things in the wrong direction and make things worse for everyone.
Con Dnfdragora needs work
As the default package installer, this piece of software needs a lot more polish. It's not explicit in saying things are installed, more granularity in package selection is needed, and the ability to move columns around to see if you're installing the correct version.
Con Slow
It is quite slow on some computers.
Con Updating to a new release can be problematic
While there are a few tools on offer that will upgrade an old Fedora release to the newest, there can often be problems with these methods. Some that may not even crop up at first but will show later down the road. Being that upgrading can be an issue, it can be exacerbated by the fact that Fedora updates every six month, which means twice a year there is a risk of completely borking ones install.
Con Proprietary drivers are unsupported
Fedora does not support proprietary drivers, meaning that users may have problems with a lot of hardware when using Fedora. The software to make that kind of hardware work can be installed, but it can be done only through third-parties and it's not easy for the average user.
Con Controlled by big corpos
Con Optimus support is straight terrible
Running on a laptop with optimus gpu or the driver for your powerful gpu is not gonna happen.
Con Unstable
Some packages may break, because there isn't an option to test them before rolling them out.
Con Not for beginners
It is not a user-friendly distro like ubuntu, PCLos. You will be required to learn a lot of commands even for simple activities.
Con 86'ed
Description of the word. Support for 32-bit architecture ended with Fedora Release 30.
Con Wayland does not work with Prime/Optimus
On a pc with hybrid video, you must use Gnome on Xorg to let the Prime or Optimus technology work.
