When comparing LaTeX vs Affinity Publisher, the Slant community recommends Affinity Publisher for most people. In the question“What are the best desktop publishing softwares?” Affinity Publisher is ranked 1st while LaTeX is ranked 4th.
Ranked in these QuestionsQuestion Ranking
Pro Lets you focus on the content
LaTeX handles the design so you can focus on the content
Pro High-quality typesetting by default
There's a reason that scholarly journals often require the use of LaTeX for articles printed in their pages, and it's because the quality of the output is that good. Universities often require, or at least encourage, the use of LaTeX for graduate theses and dissertations for this same reason.
Pro Free open source software
Licensed under the LaTeX Project Public License
You can edit LaTeX sources in any text editor.
Works on every major OS and gives exactly the same quality output everywhere you go. LaTeX on macOS, Windows, Linux, BSD, and even Mac OS 9 has exactly the same output for a given set of sources.
Pro Effortless math input
The whole reason that TeX -- and, by extension, LaTeX -- exists is to give people an easy way (well, for some value of "easy") to produce high-quality documents with properly laid out mathematical expressions and text in them. As long as you know the language (or have a reference sheet handy), you can include mathematical expressions in your document with little to no extra effort needed on your part.
Pro One-off reasonable price, with no upgrades or monthly subs
Pro Very comprehensive set of features
Pro Has become sufficiently popular over the past year that there is an excellent knowledge base
You can quickly find solutions, tutorials, etc. online when you need help. Contrast this to Scribus, which despite its rich feature set, is often unintuitive and awkward to use, and help from other users sometimes difficult to find.
Pro Lots of Resources to Learn
Serif's forums, videos and other sites offer good resources to learn this tool, which has a very intuitive interface.
Pro Most intuitive interface
Con Steep learning curve
LaTeX is not what you'd consider easy to use, and while there's plenty of documentation out there, much of it is rather opaque unless you're a seasoned TeXnician.
Con Single-threaded design
LaTeX is single-threaded by design, since it must necessarily work sequentially to produce each page as it is laid out by the typesetting engine. This makes it dependent on the power of just one individual core in your multi-core computer setup and so migrating to a machine with more cores won't necessarily make your LaTeX documents build faster.
Con Not a what-you-see-is-what-you-get editor
LaTeX uses the paradigm what-you-see-is-what-you-mean instead.
Con No EPub options (yet?)
Con No Linux version available
Unfortunately, there is no Linux version available in 2021, despite of numerous requests of the users.