When comparing MIT/GNU vs Guile, the Slant community recommends Guile for most people. In the question“What are the best Lisp dialects?” Guile is ranked 4th while MIT/GNU is ranked 7th. The most important reason people chose Guile is:
Guile makes it easy for users of your application to write extensions without needing to understand the plumbing of your program.
Specs
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Pros
Pro Easy to customize and extend applications
Guile makes it easy for users of your application to write extensions without needing to understand the plumbing of your program.
Pro GNU's official extension language
Chances are a system running enough GNU software will already have it installed.
Pro Excellent documentation
The documentation provides conceptual overviews, tutorials, and a detailed reference for all commands, functions, and operators.
Pro Fantastic interface to C, C++ in both directions, embedding guile in C/C++ and embedding C/C++ in guile
Cons
Con Not made to run as standalone
Cannot be compiled to a standalone executable, only to byte code that can be run from the interpreter; and cannot be conveniently interpreted by the interpreter from the command line.
Con Not very well-documented
The documentation is very sparse.
Con Poor Windows support
Con Ill-designed interpreter's interface
The interpreter does not support the use of the left and right arrows to move the cursor in the code and the use of the up and down arrows to navigate through the history.
Con Weak copyleft
LGPL