When comparing Notmuch vs Mutt, the Slant community recommends Mutt for most people. In the question“What are the best command-line email clients for Linux?” Mutt is ranked 1st while Notmuch is ranked 4th.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Lets you pick the tools you prefer to compose, send and receive email
Notmuch is a highly modular email client. It only focuses on browsing and managing email, leaving to the user the freedom to choose the tools with which to do all the other tasks.
Pro Terminal based
Pro Small and efficient
Pro Active development
Even though it was first released in 1995, Mutt still enjoys an active community following it and having new releases constantly.
Pro It runs inside the terminal
It doesn't display HTML email, fonts, or graphical elements.
Pro Compose mails in your favorite editor
Edit mails efficiently with an editor you already can work fluently with.
Pro Highly configurable macros
Pro Threads emails
Pro Work with regular expressions
Mails can be filtered, deleted, flagged, etc. with regular expressions which makes mail management very efficient.
Cons
Con Terminal-based
It runs inside the terminal so it doesn't display HTML email, fonts, or graphical elements.