When comparing Tkinter vs wxWidgets, the Slant community recommends wxWidgets for most people. In the question“What are the best cross-platform GUI toolkits?” wxWidgets is ranked 1st while Tkinter is ranked 20th. The most important reason people chose wxWidgets is:
wxWidgets was started in 1992 by Julian Smart.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Free for commercial use
Pro Included in the standard Python library
You probably already have it, since it's included in the standard Python distributions.
Pro Easy to learn and get productive with
TkInter is a small library with a gentle learning curve compared to what’s out there. It has a straightforward API and is often the go-to choice for building quick GUIs for Python scripts.
Pro Building executables is less complicated
Compared to other GUI libraries, building executables for TkInter applications are simpler because TkInter is included in Python and has no other dependencies. This results in less complicated packaging requirements and smaller binary size.
Pro Fast
Pro Mature
wxWidgets was started in 1992 by Julian Smart.
Pro Truly native look and feel
It uses the platform's native API rather than emulating the GUI.
Pro Open source
wxWidgets can be used for free or commercial projects, at no cost.
Pro Can do custom control rendering
You can make a custom renderer using the class wxDelegateRendererNative to draw directly any standard control or using the class BackgroundWindow to use any bitmap as a control background.
Pro Forms designers
Several forms designers, like wxFormBuilder, are available.
Pro Designer
A very nice designer: wxCrafter. Free for non-commercial use/evaluation phase (without time expiration). Highly recommended if you plan to use wxWidgets.
Pro Perfect combination: wxFormBuilder + ZeroBrane (wxLua)
Lua Language can provide extra high level scripting
Pro Can use Qt on X11
WxQt is available on X11.
Cons
Con No advanced widgets
TkInter does not come with advanced widgets out of the box (e.g. date picker).
Con Not good looking
You need a lot of code to make it look good.
Con No reliable UI builder available
There is no tool in the same league as Qt Designer (PyQt) for TkInter.
Con Android port not totally usable yet
See WxAndroid.
Con Uses GTK on X11
WxWidgets uses GTK+ on X11 desktop which well known for looking like an alien on non GTK+ desktops.