When comparing Tkinter vs Tk, the Slant community recommends Tk for most people. In the question“What are the best cross-platform GUI toolkits?” Tk is ranked 9th while Tkinter is ranked 20th. The most important reason people chose Tk is:
Once you understand how to style, the styling can look great.
Specs
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Pros
Pro Free for commercial use
Pro Included in the standard Python library
You probably already have it, since it's included in the standard Python distributions.
Pro Easy to learn and get productive with
TkInter is a small library with a gentle learning curve compared to what’s out there. It has a straightforward API and is often the go-to choice for building quick GUIs for Python scripts.
Pro Building executables is less complicated
Compared to other GUI libraries, building executables for TkInter applications are simpler because TkInter is included in Python and has no other dependencies. This results in less complicated packaging requirements and smaller binary size.
Pro Fast
Pro Easy styling
Once you understand how to style, the styling can look great.
Pro Great for beginners
Easy to pick up and run with it.
Pro Easy and good looking in Mac, Linux and Windows
Pro Bindings for several languages
Bindings for Python, C, C++, Ruby, Perl, Go, Java, Haskell and more, see Languages with a Tk binding.
Cons
Con No advanced widgets
TkInter does not come with advanced widgets out of the box (e.g. date picker).
Con Not good looking
You need a lot of code to make it look good.
Con No reliable UI builder available
There is no tool in the same league as Qt Designer (PyQt) for TkInter.
Con Base looks are garbage without a good amount of styling
Going with the base look for your app is a bad idea because it looks like garbage with the defaults.
Con C# support lacking
Although the Eagle Project exists, which offers Mono and .NET Core support, C# support is not standard.