When comparing Tkinter vs MD Python Designer, the Slant community recommends Tkinter for most people. In the question“What are the best Python GUI frameworks/toolkits?” Tkinter is ranked 3rd while MD Python Designer is ranked 15th.
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Pros
Pro Free for commercial use
Pro Included in the standard Python library
You probably already have it, since it's included in the standard Python distributions.
Pro Easy to learn and get productive with
TkInter is a small library with a gentle learning curve compared to what’s out there. It has a straightforward API and is often the go-to choice for building quick GUIs for Python scripts.
Pro Building executables is less complicated
Compared to other GUI libraries, building executables for TkInter applications are simpler because TkInter is included in Python and has no other dependencies. This results in less complicated packaging requirements and smaller binary size.
Pro Fast
Pro Amazing array of uses
The GUI Designer is compatible with all the features of the software. It is compatible with all major databases. They have an interesting GUI database form on their webpage. The GUI can also include graphs and you can create applications like desmos. You can also use ICP DAS, LabJack and Advantech devices.
Pro No adjustment required
The GUI designer has more than one coding language that it's compatible with, however it works well with Python. The transition from Kivy is easy.The GUI Designer is super easy to use and saves lots of time.
Cons
Con No advanced widgets
TkInter does not come with advanced widgets out of the box (e.g. date picker).
Con Not good looking
You need a lot of code to make it look good.
Con No reliable UI builder available
There is no tool in the same league as Qt Designer (PyQt) for TkInter.
Con Visual appearance compared to other GUI frameworks/Designers
The end product did not look as appealing as it would have done with a different GUI Designer. However, it still looked professional and got the job done perfectly.