When comparing iTerm2 vs MacDown, the Slant community recommends iTerm2 for most people. In the question“What are the best developer tools for Mac OSX?” iTerm2 is ranked 2nd while MacDown is ranked 4th. The most important reason people chose iTerm2 is:
Other than being able to customize the various shortcuts, iTerm2 also lets you customize the colorscheme, font, transparency, etc.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Extremely customizable
Other than being able to customize the various shortcuts, iTerm2 also lets you customize the colorscheme, font, transparency, etc.
Pro Autocomplete is built-in
iTerm has autocomplete features built in. It remembers your past commands and when you are writing something on the terminal, simply pressing Control-;
it will show you a drop down menu of suggestions from which to choose.
Pro Complete out of the box
Unlike most terminal emulators, iTerm2 comes with a pretty complete set of features. It has built-in search, autocompletion, tabbed navigation, Growl support and even a built-in clipboard manager for various API keys and such.
Pro Fine tuning for fonts
It's possible to choose a font and adjust vertical and horizontal spacing.
Pro Can immediately open files inside a text editor
You can Ctrl+Click on a file path to open said file in a text editor.
Pro Supports mouse actions
Has support for mouse actions like clicking, dragging, selecting, etc.
Pro Active maintainers
Issues resolved fast by quality contributors.

Pro Works well with powerline fonts
Pro Completely free and open source
iTerm2 is completely free and open source. It's released under the GPLv2 license.
Pro Split panes
Easy to split panes to either horizontal or vertical sections. Makes it easy to observe multiple console windows.
Pro Supported by many applications as a terminal app selection
If an application has terminal integration, there is high probability it allows iTerm2 to be selected.
Pro Cmd+Shift+I to Input all
Wanna SSH your server from multiple tabs, here you go.
Pro Intuitive
Pro You only need to type in commands once
iTerm2 can store up to 4M of history of commands you already used. This, coupled with the built-in search features makes it possible to type a command only once and then search for it through the history for subsequent uses.
Pro Works perfect with Oh My Zsh
It's a perfect base to add Oh My Zsh on top of it and enjoy a lot of themes and a really pleasant look and feel.
Pro Works well with tmux
The great mouse and clipboard support that are built-in go really well with tmux.
Pro Any key can be mapped to any function
Using the Preferences Menu you can set up hotkeys to map virtually any action you can think of to a single key or a combination of them. This is extremely helpful as it allows you to use shortcuts to edit commands you are typing in the terminal and while most terminal emulators have shortcuts for this sort of thing, few of them let you define your own.
Pro GPU-rendered, blazing fast and super smooth
Many people say they use Kitty or Alacritty because they are GPU-rendered. That was true a long time ago. But iTerm2 has been GPU rendered for years now. It's so fast and smooth that you soon forget you are in a terminal.
Pro Beautiful, minimalistic and elegant UI
It's super-clean and during use it gets completely out of the way, it's a beautiful canvas for your terminal work, a pure joy that never gets old.
Pro Can be configured as a drop-down terminal
Can be configured to work as a drop down terminal like Quake.
Pro Cmd+D to split plane vertically
Very handy to use multi-tab.

Pro Free and open source
MacDown is a free and open source editor influenced by Mou. It's released under the MIT license.

Pro Real-time split-screen preview
MacDown's main view is split into two panels. The user types on the left and the Markdown is rendered on the fly in the right panel. This helps users to better understand the way they are formatting their document.
Pro Markdown previews can be customized with CSS
You can use a CSS file to customize the rendered output and the file preview you are working on will display the rendered Markdown with the custom CSS styling on top.

Pro Supports syntax highlighting in fenced code blocks
MacDown has syntax highlighting support for various languages when writing code in fenced code blocks.
Pro Good auto-completion
MacDown has a good built-in auto-completion engine for Markdown symbols.

Pro Support for GFM
Pro Ideal for day-to-day programmers' work and MarkDown novices alike
Using MacDown for the notorious README.md use case gets you going without reading any manual or requiring any configuration values. Think of it as a sort of TextEdit for MarkDown files. Thus its shortcomings - neither powerful nor versatile - turn out to be a PRO for novices trying to jump on the MarkDown bandwagon. Open its help and you'll immediately find yourself editing the MacDown's MarkDown help file, a MarkDown primer with some MacDown menus and configuration added.
Pro Linking between pages
Unlike a few other editors, MacDown lets you link between markdown pages.
Pro Tool bar with most used markdown shortcuts
This is especially useful for Markdown novices
Cons
Con Keycodes are not passed through following Linux standards
If you come from a Linux terminal emulator (Gnome Terminal, Konsole...) and you rely on key-combos that are widely supported in those, porting the same functionality to iTerm is possible but will require a lot of research and configuration on your part, so account for a long painful adoption period.
Con Not quite as fast as Alacritty or Kitty
Comparing these 3 terminals on the same machine/config, iTerm stands out as the slowest of the bunch. The difference may not be noticeable to all users.
Con Way too many menu items and settings
Finding the right one is like searching for a needle in a haystack.
Con Doesn't support Snow Leopard 10.6.8
Some people still use Snow Leopard or other 32-bit systems.
Con Doesn't support RTL
Con Not very versatile
MacDown is not very powerful or versatile. It's not customizable or extendable. This is what makes it so simple, but it's not for people who want more from their tools.
Con Frequently fails to update the display and/or flat out hangs
Must often restart MacDown.
Con The Markdown preview is rather heavy on the CPU
The Markdown preview needs a lot of resources to keep rendering on-the-fly after each keystroke. A single keystroke in the editor panel may trigger up to 5 seconds of max-CPU usage.
